Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Unusual Case of Primary Plasma Cell Leukemia Presenting As Pericardial Effusion.

Cureus·2025
Same author

GIS mapping of agricultural plastic waste in southern Europe.

The Science of the total environment·2024
Same author

Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents.

International journal of molecular sciences·2023
Same author

Lamotrigine-associated haemophagocytic lymphohistiocytosis (HLH) confounded with underlying rheumatoid arthritis.

BMJ case reports·2022
Same author

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues.

Organic & biomolecular chemistry·2021
Same author

New or Worsened Mitral Regurgitation After Surgical Aortic Valve Replacement: A Systematic Review.

Seminars in cardiothoracic and vascular anesthesia·2020
Same journal

<i>ARID1A</i> Expression is Down-Regulated by Oxidative Stress in Endometriosis and Endometriosis-Associated Ovarian Cancer.

Translational oncogenomics·2017
Same journal

The Role of Genomic Profiling in Advanced Breast Cancer: The Two Faces of Janus.

Translational oncogenomics·2016
Same journal

Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics.

Translational oncogenomics·2016
Same journal

Interplay Between Metabolism and Oncogenic Process: Role of microRNAs.

Translational oncogenomics·2016
Same journal

c-Met as a Target for Personalized Therapy.

Translational oncogenomics·2015
Same journal

Precision Medicine for Molecularly Targeted Agents and Immunotherapies in Early-Phase Clinical Trials.

Translational oncogenomics·2015
See all related articles

Related Experiment Video

Updated: May 11, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

The oncogene mcts1.

Ali Hachem1, Suvobroto Nandi

  • 1The Cancer Center of Huntsville, Huntsville, AL 35801.

Translational Oncogenomics
|May 7, 2013
PubMed
Summary
This summary is machine-generated.

The MCTS1 oncogene promotes cancer growth by affecting cell cycle progression and acting as a translational activator. Its role in modulating the MAPK pathway contributes to aggressive properties and inhibits apoptosis in breast cancer.

Keywords:
DNA damageangiogenesiscell cycleoncogenepseudogene

More Related Videos

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Related Experiment Videos

Last Updated: May 11, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • The MCTS1 oncogene was identified as an amplified product in T-cell lymphoma.
  • MCTS1 has been linked to cell cycle progression and growth advantages in lymphomas and breast cancer.
  • Recent studies indicate MCTS1 modulates the MAPK pathway and functions as a translational activator.

Purpose of the Study:

  • To review the data on the oncogene MCTS1.
  • To discuss the implications of MCTS1 in cancer understanding.
  • To highlight MCTS1's role in aggressive cancer properties.

Main Methods:

  • Literature review of existing research on MCTS1.
  • Analysis of MCTS1's function in cell cycle progression.
  • Investigation of MCTS1's role in MAPK pathway modulation and translation activation.

Main Results:

  • MCTS1 expression confers aggressive properties in breast cancer cells.
  • MCTS1 inhibits apoptosis in breast cancer.
  • MCTS1 acts as a translational activator both in vivo and in vitro.

Conclusions:

  • MCTS1 plays a significant role in promoting cancer growth and progression.
  • Understanding MCTS1's function provides insights into cancer development.
  • MCTS1 represents a potential target for cancer therapies.