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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Amphiphilic poly(L-aspartic acid) copolymer nanoparticles for cyclosporine A delivery
Siyuan Han1, Yun Sun, Shishuai Su
1National Center for Nanoscience and Technology, China, Beijing 100190, China.
Abstract:
In this paper, novel cyclosporine A (CsA)-loaded amphiphilic poly(L-aspartic acid-co-L-lactic acid) (PAL)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) copolymer nanoparticles (NPs) were successfully fabricated using an emulsion/solvent evaporation technique. The CsA-loaded NPs were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The CsA-loaded NPs size, size distribution, encapsulation efficiency (EE) and drug-loading content (LC) were influenced by polyvinyl alcohol (PVA) concentration and the weight ratio of the copolymer to CsA. In vitro release behavior of CsA-loaded NPs showed a sustained release. With the increasing of copolymer/CsA weight ratio, the release of CsA from NPs is rapid. The poly(L-aspartic acid) derivatives NPs have a promising potential in hydrophobic drug delivery system.

