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Updated: May 11, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
Published on: August 5, 2021
Osteoblastic cell response and bone formation of phosphate ion coated on plasma polymerized Ti surface
Seong-Won Yang1, Kang Lee, Byung-Hoon Kim
1Department of Ophthalmology, Chosun University College of Medicine, Gwangju, 501-759 Korea.
Abstract:
This study examined the bone formation ability and cell response on a phosphate (PO3(4-)) ion exchanged amine plasma polymerized titanium (Ti) surface. The enhanced bone-like apatite (hydroxyapatite, HAp)-forming ability was attributed to the PO3(4-) ion exchanged amine plasma polymerized Ti (P/NH2/Ti) surface, which was formed by the reduction of PO3(4-) ions. PO3(4-) ions promote HAp nucleation and growth on Ti in SBF, and PO3(4-) ions improve the crystallinity of the HAp deposited layer. The cell viability tests revealed significantly greater cell viability on the P/NH2/Ti surfaces than on the other surfaces.
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