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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Updated: May 11, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Published on: February 8, 2017

A pH-sensitive charge-conversion system for doxorubicin delivery.

Xiuwen Guan1, Yanhui Li, Zixue Jiao

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Acta Biomaterialia
|May 8, 2013
PubMed
Summary
This summary is machine-generated.

A novel pH-sensitive drug delivery system uses charge conversion for enhanced cancer treatment. This system shields the drug in normal tissues and releases it in acidic tumor environments, improving efficacy.

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Published on: June 23, 2020

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Developing targeted drug delivery systems is crucial for improving cancer therapy efficacy.
  • pH-sensitive materials offer a promising strategy for tumor-specific drug release.
  • Conventional chemotherapy faces challenges like systemic toxicity and poor drug accumulation in tumors.

Purpose of the Study:

  • To design and evaluate a novel pH-sensitive charge-conversion shielding system for enhanced doxorubicin delivery.
  • To investigate the pH-responsive behavior and drug release characteristics of the designed system.
  • To assess the cellular uptake, intracellular drug release, and anticancer efficacy of the system in vitro.

Main Methods:

  • Fabrication of polyethylenimine (PEI)-poly(l-lysine)-poly(l-glutamic acid) (PELG) shielded cis-aconityl-doxorubicin (CAD) complexes.
  • Characterization of charge conversion using zeta potential analysis at varying pH.
  • Evaluation of pH-dependent doxorubicin release kinetics.
  • Assessment of cellular uptake and intracellular drug delivery via confocal microscopy.
  • Cytotoxicity assays against cancer cells.

Main Results:

  • The PELG/PEI/CAD complexes exhibited pH-dependent charge reversal, becoming positive in acidic conditions (pH 6.8).
  • Doxorubicin release significantly increased as pH decreased.
  • Enhanced cellular uptake and nuclear accumulation of doxorubicin were observed at pH 6.8.
  • The system demonstrated remarkable cytotoxicity against cancer cells, indicating effective drug delivery.

Conclusions:

  • The developed pH-sensitive charge-conversion shielding system effectively delivers doxorubicin to cancer cells.
  • The combination of pH-triggered charge conversion and drug release enhances anticancer activity.
  • This system holds significant potential as a drug delivery platform for tumor treatment.