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Updated: May 11, 2026

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A rational approach towards a new ferrocenyl pyrrolidine for stereoselective enamine catalysis
Diego Petruzziello1, Marco Stenta, Andrea Mazzanti
1ALMA MATER STUDIORUM, Dipartimento di Chimica G. Ciamician, Via Selmi 2, 40126 Bologna, Italy.
Abstract:
Ironing out the details: Proline and pyrrolidine derivatives (Hayashi- Jørgensen catalysts) are considered "work horses" in organocatalysis. This report describes a new effective ferrocenyl pyrrolidine catalyst that is able to perform well in benchmark organocatalytic reactions (see figure). The ferrocene moiety controls the conformational space and a simple alkyl group effectively covers a face of the derived enamine. This new framework can find applications in organocatalysis, and in general, in new ligand design.
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