Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Megakaryocytes Internalize and Are Activated by Immune Complexes.

Circulation research·2026
Same author

Building Equitable Linkages with Interprofessional Education Valuing Everyone (BELIEVE): research protocol for a multisite step-wedge cluster randomized trial.

BMC pregnancy and childbirth·2026
Same author

Functional characterization of Furin-mediated lipoprotein lipase cleavage.

Disease models & mechanisms·2026
Same author

Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma.

Research and practice in thrombosis and haemostasis·2026
Same author

Associations between sedentary behavior and allostatic load: The 1970 British Cohort Study.

Psychoneuroendocrinology·2026
Same author

Efficacy of the serogroup B <i>Neisseria meningitidis</i> vaccine (4CMenB) in preventing experimental <i>Neisseria gonorrhoeae</i> urethral infection: a double-blind randomised controlled human challenge study protocol.

BMJ open·2026
Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026
Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026
Same journal

Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.

Annals of biomedical engineering·2026
Same journal

Numerical Study of Human Torso Mechanical Response and Injury Assessment Under Blast Loading with Bulletproof Protection.

Annals of biomedical engineering·2026
Same journal

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026
Same journal

Screening and Evaluation of Post-stroke Dysphagia: Insights from Neurology, Artificial Intelligence and Data Science-A Scoping Review.

Annals of biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

High sensitivity micro-elastometry: applications in blood coagulopathy.

Gongting Wu1, Charles R Krebs, Feng-Chang Lin

  • 1Department of Physics and Astronomy, University of North Carolina at Chapel Hill, CB 3255, Chapel Hill, NC 27599, USA.

Annals of Biomedical Engineering
|May 8, 2013
PubMed
Summary
This summary is machine-generated.

Resonant acoustic spectroscopy with optical vibrometry (RASOV) is a new, sensitive method for measuring clot elastic modulus (CEM). This technique accurately assesses clot structure and detects hyperfibrinogenemia, aiding coagulation disorder research.

More Related Videos

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow
09:41

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

Related Experiment Videos

Last Updated: May 11, 2026

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow
09:41

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Biophysics

Background:

  • Accurate clot structure assessment is crucial for understanding coagulation disorders and guiding cardiovascular disease treatment.
  • Current diagnostic methods may require large sample volumes or lack sufficient repeatability.

Purpose of the Study:

  • To introduce resonant acoustic spectroscopy with optical vibrometry (RASOV) as a novel micro-elastometry technique for clot analysis.
  • To evaluate RASOV's sensitivity, repeatability, and correlation with existing methods.
  • To assess RASOV's ability to detect changes in clot structure related to fibrinogen levels and hypercoagulability.

Main Methods:

  • Developed RASOV, a micro-elastometry method measuring clot elastic modulus (CEM) via intrinsic resonant frequency in a microwell.
  • Compared RASOV measurements of human blood CEM with a commercial thromboelastograph (TEG).
  • Assessed RASOV's sensitivity to varying fibrinogen concentrations and conversion rates in purified clots.
  • Simulated hypercoagulability by increasing fibrinogen levels in whole blood and measured CEM changes using RASOV.

Main Results:

  • RASOV demonstrated a high correlation (R=0.966) with TEG for human blood CEM measurement.
  • RASOV requires significantly less sample volume (150 μL) and shows improved repeatability compared to TEG.
  • RASOV accurately detected changes in CEM with varying fibrinogen concentrations (0.5-6 mg/mL) and fibrin conversion.
  • RASOV successfully identified hyperfibrinogenemia-induced alterations in CEM, distinguishing them from normal blood.

Conclusions:

  • RASOV is a highly sensitive, repeatable, and low-volume method for measuring clot elastic modulus (CEM).
  • RASOV effectively assesses clot structure and is sensitive to fibrinogen levels and hypercoagulability.
  • RASOV shows promise as a valuable tool for research into coagulation disorders and cardiovascular diseases.