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Updated: May 11, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Can intermittent dosing optimize prolonged linezolid treatment of difficult multidrug-resistant tuberculosis?
Kwok-Chiu Chang1, Wing-Wai Yew, Siu-Wai Cheung
1Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China.
Abstract:
We evaluated treatment with linezolid, dosed at 800 mg once daily for 1 to 4 months as guided by sputum culture status and tolerance and then at 1,200 mg thrice weekly until ≥ 1 year after culture conversion, in addition to individually optimized regimens among 10 consecutive patients with extensively drug-resistant tuberculosis or fluoroquinolone-resistant multidrug-resistant tuberculosis. All achieved stable cure, with anemia corrected and neuropathy stabilized, ameliorated, or avoided after switching to intermittent dosing. Serum linezolid profiles appeared better optimized.
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