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Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
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Updated: Dec 31, 2025

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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[H1-antihistamines].

Luo Zhang1, Demin Han

  • 1dr.luozhang@gmail.com

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|May 9, 2013
PubMed
Summary
This summary is machine-generated.

H1-antihistamines are a cornerstone in treating allergic diseases like allergic rhinitis. This review covers their history, discovery, receptors, mechanisms, and safety.

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Area of Science:

  • Pharmacology
  • Immunology
  • Allergy Research

Context:

  • Histamine is crucial in allergic disease pathogenesis, including allergic rhinitis.
  • H1-antihistamines have been a primary treatment for over 70 years.

Purpose:

  • To review the history of histamine research and H1-antihistamine discovery.
  • To discuss histamine receptors, H1-antihistamine mechanisms, and safety profiles.

Summary:

  • This review explores the historical development and scientific basis of H1-antihistamines.
  • It details histamine's role in allergies and the therapeutic actions of H1-antihistamines.
  • Key aspects covered include receptor interactions, mechanisms of action, and safety considerations.

Impact:

  • Provides a comprehensive overview of H1-antihistamines for researchers and clinicians.
  • Highlights the enduring importance of H1-antihistamines in managing allergic conditions.
  • Contributes to understanding the long-term safety and efficacy of these established treatments.