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Updated: May 11, 2026

Fatty Acid 13C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers
Published on: April 17, 2018
Manzamenone O, new trimeric fatty acid derivative from a marine sponge Plakortis sp
Naonobu Tanaka1, Miki Asai, Azusa Takahashi-Nakaguchi
1Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan, Mycology Research Center, Chiba University , Chiba 260-0856, Japan, and Western Australian Museum , Locked Bag 49, Weishpool DC, WA 6986, Australia.
Abstract:
A new structurally unique trimeric fatty acid derivative, manzamenone O (1), was isolated from a marine sponge Plakortis sp. Manzamenone O (1) has a novel skeleton consisting of C-C bonded octahydroindenone and dioxabicyclo[3.3.0]octane moieties and three long aliphatic chains. The structure of 1 was elucidated on the basis of spectroscopic data and conformational analysis. Manzamenone O (1) exhibited antimicrobial activity against Micrococcus luteus, Aspergillis niger, and Trichophyton mentagrophytes.
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