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Updated: May 11, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Role of microRNA deregulation in breast cancer cell chemoresistance and stemness

T A Tekiner1, H Basaga

  • 1Biological Sciences and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Orhanli-Tuzla, 34956 Istanbul, Turkey.

Current Medicinal Chemistry
|May 9, 2013
PubMed

Insights

MicroRNAs (miRNAs) regulate key pathways in breast cancer progression and chemoresistance. Targeting these miRNAs and cancer stem-like cells (CSCs) offers new therapeutic strategies and biomarkers for improved anti-cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are crucial regulators of signaling pathways involved in breast cancer progression.
  • Altered miRNA expression and genetic variations (SNPs) in miRNA genes contribute to tumor growth, metastasis, angiogenesis, and drug resistance.
  • miRNAs influence cancer stem-like cells (CSCs), which are inherently resistant to conventional therapies and impede cancer cure.

Purpose of the Study:

  • To review the role of miRNAs in breast cancer chemoresistance.
  • To discuss the involvement of breast cancer stem cells (CSCs) in chemotherapy resistance.
  • To highlight miRNAs as potential biomarkers and therapeutic targets for novel anti-cancer strategies.

Main Methods:

  • Literature review of studies on microRNAs and breast cancer.
  • Analysis of research on miRNA deregulation and its impact on tumor signaling pathways.
  • Examination of the role of miRNAs in cancer stem cell self-renewal and signal transduction.

Main Results:

  • miRNAs are key regulators of signaling pathways critical for tumor progression.
  • miRNA deregulation, including SNPs, drives tumor growth, metastasis, angiogenesis, and chemoresistance.
  • miRNAs impact CSCs, contributing to therapy resistance and incomplete cancer eradication.

Conclusions:

  • miRNAs are implicated in breast cancer chemoresistance.
  • Breast CSCs play a significant role in the ineffectiveness of chemotherapy.
  • miRNAs represent promising novel biomarkers and therapeutic targets for developing advanced anti-cancer therapies.

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