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Updated: May 11, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Medication reconciliation is a prerequisite for obtaining a valid medication review
Mette Bjeldbak-Olesen1, Anja Gadsbølle Danielsen, Dorthe Vilstrup Tomsen
1Pharmacy of the Capital Region, Hillerød Hospital, Hillerød, Denmark.
Medication reconciliation found more errors, but medication review identified more serious drug-related problems (DRPs). Both methods are crucial for comprehensive patient safety and should be used together.
Area of Science:
- Clinical Pharmacy
- Patient Safety
- Medication Management
Background:
- Medication errors and drug-related problems (DRPs) pose significant risks to patient safety.
- Effective methods for identifying and mitigating these errors are essential in clinical practice.
Purpose of the Study:
- To compare the effectiveness of medication reconciliation and medication review in identifying discrepancies and DRPs.
- To assess the number, type, and severity of errors detected by each method.
Main Methods:
- A retrospective study was conducted in a cardiology department.
- Medication reconciliation involved comparing patient records, electronic medication systems (EMS), and discharge summaries (DS).
- Medication review was based solely on the EMS, with errors assessed using a four-point scale for clinical importance.
Main Results:
- Medication reconciliation identified 198 discrepancies (2.6/patient), with omissions and record-EMS discrepancies being most common. 15% were potentially serious or fatal.
- Medication review identified 129 DRPs (1.7/patient), with sub-therapeutic dosage and inappropriate regimens being most frequent. 35% were potentially serious or fatal.
- While reconciliation found more errors overall, review identified a higher proportion of serious errors.
Conclusions:
- Medication reconciliation and medication review detect different types of errors.
- Medication review identified a higher percentage of serious drug-related problems.
- Both methods are complementary and should be used concurrently to enhance patient safety and medication management.
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