Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increasing the efficiency of cone-beam CT based delta-radiomics using automated contours to predict radiotherapy-related toxicities in prostate cancer.

Scientific reports·2024
Same author

Cone beam CT-based adaptive intensity modulated proton therapy assessment using automated planning for head-and-neck cancer.

Radiation oncology (London, England)·2024
Same author

The AAPM/ASTRO 2023 Core Physics Curriculum for Radiation Oncology Residents.

International journal of radiation oncology, biology, physics·2023
Same author

Predictors of Local Recurrence and Progression-Free Survival in Iodine-125 Brachytherapy-Treated Uveal Melanomas: A Modern Institutional Study.

Ocular oncology and pathology·2023
Same author

CivaSheet® use for soft tissue sarcoma: A single institution experience.

Brachytherapy·2023
Same author

Cone-beam CT delta-radiomics to predict genitourinary toxicities and international prostate symptom of prostate cancer patients: a pilot study.

Scientific reports·2022

Related Experiment Video

Updated: May 11, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Effective dose to patients and staff when using a mobile PET/SPECT system.

Matthew T Studenski1

  • 1Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA. Matthew.Studenski@JeffersonHospital.org

Journal of Applied Clinical Medical Physics
|May 9, 2013
PubMed
Summary

Determining weekly mobile PET/SPECT scanner acquisitions for cardiac imaging in ICUs requires careful dose management. Reducing administered activity or using shielding allows more myocardial perfusion/viability scans within regulatory limits.

More Related Videos

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Related Experiment Videos

Last Updated: May 11, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Area of Science:

  • Nuclear Medicine
  • Radiological Physics

Background:

  • Mobile PET/SPECT scanners offer advanced cardiac imaging in intensive care units (ICUs).
  • Assessing radiation dose to patients and staff is crucial for safe implementation.

Purpose of the Study:

  • To determine the maximum number of weekly myocardial perfusion/viability imaging acquisitions using mobile PET/SPECT in ICUs.
  • To ensure compliance with regulatory effective dose limits for patients and staff.

Main Methods:

  • Calculated effective dose to patients and staff following AAPM TG-108 recommendations.
  • Determined weekly acquisition limits based on CFR 10 CFR 20 for Tc-99m and F-18.
  • Evaluated dose reduction strategies including activity decrease and portable shielding.

Main Results:

  • A single weekly Tc-99m myocardial perfusion scan is permissible at 455 MBq without shielding.
  • A single weekly F-18 myocardial viability scan requires activity reduction to 220 MBq without shielding.
  • Multiple weekly acquisitions are feasible with additional shielding or further activity reduction.

Conclusions:

  • A validated method for calculating ICU radiation dose from mobile PET/SPECT was developed.
  • Clinic-specific dose calculations are necessary before initiating acquisitions.
  • Optimizing activity and shielding enables increased utilization of mobile cardiac imaging in ICUs.