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Subclinical cerebral abnormalities in chronic kidney disease
Hiroshi Yao1, Yuki Takashima, Manabu Hashimoto
1Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Saitama, Japan. hyao@hizen2.hosp.go.jp
Contributions to Nephrology
|May 9, 2013
Summary
Elderly individuals with late-stage chronic kidney disease (CKD) face a higher risk of subclinical lacunar infarction. Identifying CKD-specific risk factors is crucial for preventing these brain lesions.
Area of Science:
- Neurology
- Nephrology
- Geriatrics
Background:
- Chronic kidney disease (CKD) is linked to increased stroke risk.
- The association between CKD and subclinical brain abnormalities is not well understood.
Purpose of the Study:
- To investigate the relationship between CKD, estimated glomerular filtration rate (eGFR), and subclinical cerebral abnormalities in elderly individuals.
Main Methods:
- Magnetic resonance imaging (MRI) was used to assess subclinical brain lesions in 675 elderly participants.
- Serum creatinine levels were measured to calculate eGFR using the Japanese equation.
Main Results:
- Subclinical lacunar infarction was present in 13.0% of participants.
- Factors associated with lacunar infarction included age, hypertension, diabetes, alcohol intake, and eGFR <45 ml/min/1.73 m².
- CKD (eGFR <60 ml/min/1.73 m²) and decreased eGFR were not significantly associated with lacunar infarction or white matter lesions (WMLs).
Conclusions:
- Late-stage 3 CKD is a significant risk factor for prevalent subclinical lacunar infarction in community-dwelling elderly individuals.
- Identifying CKD-specific modifiable risk factors is essential for preventing subclinical brain ischemic lesions.
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