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Updated: May 11, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Nuclear receptor LXR: a new partner for sodium-dependent phosphate cotransporters
Yupanqui Caldas1, Hector Giral, Victor Sorribas
1Division of Renal Diseases and Hypertension, University of Colorado-Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA.
Abstract:
New pharmaceutical research approaches are focusing on trying to alleviate the perturbed phosphate (Pi) homeostasis associated with the onset of chronic kidney disease; this includes activation of some of the nuclear receptors. We have recently reported the down regulation of the intestinal and renal sodium-phosphate (NaPi) cotransporters by the liver X receptor (LXR) agonists, and the consequent decrease of the serum Pi levels. In this review, we describe our current knowledge of the different proteins involved in the renal and intestinal actions of LXR.
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