[Observation of morphological genesis and histochemistry of pulmonary adenocarcinoma in mice]

In the developing process of pulmonary adenocarcinoma in mice induced by N-methyl-N'-nitro-N-nitrosoguanidine, the observations of histological pathology, ultrastructure and the changes of enzyme activity of the lesions related to pulmonary adenocarcinoma were made by light microscopy, transmission electron microscopy and enzyme histochemistry, by sacrificing animals at intervals. The results indicated that there was a series of precancerous lesions before the initiation of adenocarcinoma; that adenoma was a kind of precancerous lesion which might develop into adenocarcinoma; and that adenoma with malignant change might be a focus of early adenocarcinoma. Based on the results of histological pathology, ultrastructure and enzyme histochemistry, a process of the morphological genesis of pulmonary adenocarcinoma in mice was proposed, and the metabolic changes related to various lesions were discussed.