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Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation
Sang-Min Lee1, De-Hao Tsai, Vincent A Hackley
1Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
Nanoscale
|May 10, 2013
Abstract
None:
We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.
