Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Silicon Dioxide Multi-Mode Interference Spectrometers.

Micromachines·2026

Same author

Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health.

Scientific reports·2025

Same author

Universal Nanopore Sensor for Amplification-Free and Label-Free Detection of Molecular Biomarkers.

ACS sensors·2025

Same author

Air Core ARROW Waveguides Fabricated in a Membrane-Covered Trench.

Photonics·2025

Same author

Observational quality control study: insourcing multi-PCR-impact on the use of anti-infectives for patients with pleocytosis.

Neurological research and practice·2025

Same author

Process evaluation of a cross-sectoral, coordinated follow-up care of stroke patients: a qualitative study.

Neurological research and practice·2025

Search research articles

Related Experiment Video

Updated: May 11, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Simultaneously acquired MR/PET images compared with sequential MR/PET and PET/CT: alignment quality.

Cornelia B Brendle¹, Holger Schmidt, Sabrina Fleischer

¹Department of Radiology, Division of Diagnostic and Interventional Radiology, Eberhard-Karls University Tuebingen, Hoppe-Seyler-Str 3, 72076 Tuebingen, Germany.

|May 10, 2013

Summary

Simultaneous MR/PET imaging offers superior anatomic alignment for abdominal organs compared to retrospective fusion and PET/CT. Thoracic MR/PET alignment is best with expiratory or free-breathing techniques, not inspiratory breath-holds.

More Related Videos

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Related Experiment Videos

Last Updated: May 11, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Area of Science:

Medical Imaging
Radiology
Nuclear Medicine

Background:

Accurate anatomic alignment is crucial for multimodal imaging fusion.
Simultaneous and retrospective fusion techniques have varying degrees of spatial accuracy.
Optimizing imaging protocols is essential for reliable diagnostic interpretation.

Purpose of the Study:

To compare the anatomic alignment accuracy of simultaneous MR/PET, PET/CT, and retrospective MR/PET fusion in the abdomen and pelvis.
To evaluate the impact of different breathing, registration, and gating protocols on thoracic MR/PET alignment.

Main Methods:

Analysis of 28 abdominal and 7 thoracic patient datasets.
Comparison of misalignment in simultaneous MR/PET, PET/CT, and retrospective MR/PET fusion.
Evaluation of various breathing (inspiratory, expiratory, free-breathing), registration, and gating protocols for thoracic imaging.

Main Results:

Simultaneous MR/PET demonstrated significantly reduced misalignment in abdominal organs compared to retrospective fusion (5.8 mm vs 11.9 mm) and PET/CT for the urinary bladder (5.9 mm vs 11.0 mm).
Thoracic MR/PET with inspiratory breath-hold showed the greatest misalignment (24.5 mm).
No significant differences were found between other thoracic protocols (sequential, gated, different registrations).

Conclusions:

Simultaneous whole-body MR/PET provides more accurate alignment than retrospective fusion for abdominal organs and PET/CT for the urinary bladder.
Expiratory breath hold or free-breathing protocols yield better thoracic MR/PET alignment than inspiratory breath-hold.
The clinical significance of observed misalignments requires further investigation.