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Updated: May 11, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Alternative ultraviolet A lamp for corneal collagen crosslinking
Manuel Diaz-Llopis1, David Salom, Salvador Garcia-Delpech
1Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain.
This study presents an affordable and accessible device for safe and reproducible collagen crosslinking. The method involves a modified ultraviolet A lamp and in-house riboflavin solution for effective treatment.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Materials Science
Background:
- Collagen crosslinking is a crucial procedure in ophthalmology.
- Existing methods can be expensive and inaccessible.
- There is a need for cost-effective and reproducible crosslinking techniques.
Purpose of the Study:
- To describe an original, affordable device for collagen crosslinking.
- To demonstrate a safe and reproducible method for this procedure.
- To enable in-house preparation of essential reagents.
Main Methods:
- Modification of an affordable ultraviolet A lamp.
- In-house preparation of 0.1% riboflavin solution.
- Performing collagen crosslinking using the modified device and in-house solution.
Main Results:
- The developed device allows for safe and reproducible collagen crosslinking.
- The in-house riboflavin preparation is effective.
- The overall procedure is cost-effective and accessible.
Conclusions:
- An original, affordable, and available device for collagen crosslinking has been developed.
- The described method ensures safety and reproducibility.
- This innovation can increase accessibility to collagen crosslinking procedures.
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