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Primary lymphoma of the colon
Revista Espanola De Enfermedades Digestivas
|May 11, 2013
Summary
Primary colorectal lymphoma, a rare non-Hodgkin lymphoma, presents diagnostic challenges. Combination therapy of surgery and chemotherapy shows promise for good remission rates in managing this condition.
Area of Science:
- Gastroenterology
- Oncology
- Hematology
Background:
- Primary colorectal lymphoma is a rare neoplasm, accounting for less than 0.5% of all colorectal tumors.
- The gastrointestinal tract is the most common extranodal site for lymphomas, predominantly non-Hodgkin lymphoma.
- Unspecific symptoms often delay early diagnosis, complicating treatment.
Purpose of the Study:
- To report the management experience of primary colorectal lymphomas over a 17-year period.
- To analyze the clinical presentation, treatment outcomes, and survival rates.
Main Methods:
- Retrospective review of 7 cases of primary colorectal lymphoma diagnosed between 1994 and 2011.
- Evaluation of patient symptoms, surgical interventions, chemotherapy, radiotherapy, and follow-up data.
Main Results:
- Abdominal pain and altered bowel habits were the most common presenting symptoms.
- Five patients required emergency surgery for complications like bleeding or obstruction.
- All studied lymphomas were B-cell phenotype; three patients achieved remission with no recurrence after a median follow-up of 59 months.
Conclusions:
- Combined surgical and chemotherapeutic approaches can achieve favorable remission rates for primary colorectal lymphoma.
- Surgical intervention is crucial for managing life-threatening complications such as bleeding and perforation, which are significant contributors to lymphoma mortality.
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