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Percutaneous ablation of lymph node metastases using CT-guided high-dose-rate brachytherapy
F Collettini1, A C Schippers, D Schnapauff
1Department of Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany. federico.collettini@charite.de
The British Journal of Radiology
|May 11, 2013
Summary
Computed tomography-guided high-dose-rate brachytherapy (CT-HDRBT) is a safe and effective minimally invasive technique for treating isolated lymph node metastases, offering a viable therapeutic option for local tumor control.
Area of Science:
- Oncology
- Radiotherapy
- Minimally Invasive Procedures
Background:
- Isolated lymph node metastases pose treatment challenges.
- Accurate local tumor control (LTC) is crucial for patient outcomes.
- Minimally invasive techniques are increasingly sought for cancer treatment.
Purpose of the Study:
- To evaluate the technical feasibility of CT-guided high-dose-rate brachytherapy (CT-HDRBT).
- To assess the safety and clinical outcomes of CT-HDRBT for LTC in isolated lymph node metastases.
- To determine the effectiveness of CT-HDRBT in achieving local tumor control.
Main Methods:
- A cohort of 10 patients with isolated nodal metastases received CT-HDRBT.
- Lesions were located in various sites including para-aortic, liver hilum, coeliac trunk, and iliac nodes.
- Follow-up included contrast-enhanced CT or MRI, with primary endpoint as LTC.
Main Results:
- CT-HDRBT demonstrated complete coverage of treated nodal metastases at 6 weeks.
- No peri-interventional mortality or major complications were observed.
- Local tumor progression occurred in 20% of patients, with a mean progression-free interval of 9.2 months.
Conclusions:
- CT-guided high-dose-rate brachytherapy is a feasible and safe technique for nodal metastases ablation.
- CT-HDRBT represents a potentially viable therapeutic alternative for selected patients.
- This method offers effective local tumor control in isolated lymph node metastases.
