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Updated: May 11, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Published on: October 16, 2013

Diverticular disease severity score based on CT colonography.

Nicola Flor¹, Paolo Rigamonti, Andrea Pisani Ceretti

¹Unità Operativa Radiologia Diagnostica e Interventistica, Azienda Ospedaliera San Paolo, via A di Rudinì 8, 20142, Milano, Italy, nicola.flor@ao-sanpaolo.it.

European Radiology

|May 11, 2013

Summary

A new Diverticular Disease Severity Score (DDSS) using CT colonography is proposed. This score, based on colon wall thickness and lumen diameter, shows high reproducibility and aids in identifying patients needing surgery.

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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

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Published on: February 14, 2021

Area of Science:

Gastroenterology
Radiology
Surgical Oncology

Background:

Diverticular disease is a common condition affecting the colon.
Accurate assessment of disease severity is crucial for effective management.
CT colonography (CTC) is a valuable imaging modality for evaluating colonic pathology.

Purpose of the Study:

To develop and validate a Diverticular Disease Severity Score (DDSS) based on CT colonography (CTC) findings.
To assess the reproducibility and clinical utility of the proposed DDSS.

Main Methods:

A cohort of 79 patients with acute diverticulitis underwent CTC.
A four-point DDSS was developed based on sigmoid colon wall thickness and lumen diameter.
Intra- and interobserver reproducibility were assessed, and DDSS was correlated with surgical and histopathological findings.

Main Results:

The DDSS demonstrated excellent intra- and interobserver reproducibility (k=0.90-0.84).
DDSS significantly correlated with the likelihood of requiring surgery (P=0.001).
A DDSS of 4 was associated with significant superimposed histopathology, including cancer, in 3 out of 32 surgically treated patients.

Conclusions:

The proposed DDSS is a highly reproducible tool for assessing diverticular disease severity via CTC.
DDSS correlates well with pathological measurements of sigmoid colon wall thickness.
This CTC-based score provides valuable information for colorectal surgeons, potentially influencing therapeutic decisions.