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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Attenuation correction for the HRRT PET-scanner using transmission scatter correction and total variation

Sune H Keller1, Claus Svarer, Merence Sibomana

  • 1Department of Clnical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark. sune@pet.rh.dk

IEEE Transactions on Medical Imaging
|May 11, 2013
PubMed
Summary

A new method called transmission processing with total variation (TXTV) reduces bias in Siemens high-resolution research tomograph (HRRT) positron emission tomography (PET) brain scans. TXTV improves image quality and is recommended for HRRT human brain imaging.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Biophysics

Background:

  • Siemens high-resolution research tomograph (HRRT) positron emission tomography (PET) brain scans can exhibit bias, particularly in the lower cerebellum and pons.
  • The standard maximum a posteriori for transmission (MAP-TR) method often struggles with accurate bone/soft tissue segmentation and bone mass estimation, leading to image artifacts.

Purpose of the Study:

  • To develop and evaluate a novel method for improved μ-map reconstruction in HRRT PET brain imaging.
  • To address the bias issues associated with the conventional MAP-TR technique.

Main Methods:

  • Development of the transmission processing with total variation (TXTV) method.
  • Incorporation of scatter correction and total variation filtering into the μ-map reconstruction process.

Main Results:

  • The TXTV method demonstrated reduced bias compared to MAP-TR when validated against CT-based attenuation correction.
  • Quantitative correspondence between TXTV-reconstructed HRRT images and GE Advance scanner images was high.
  • TXTV has been successfully implemented in over 4000 HRRT scans across seven sites without reported biases.

Conclusions:

  • The TXTV-based reconstruction method is recommended for human brain scans utilizing the HRRT scanner.
  • TXTV offers a more accurate and reliable approach to attenuation correction in HRRT PET imaging.