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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
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Published on: June 14, 2018

Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT

Per Jensen1,2, Brice Ozenne1,3, Per Meden4

  • 1Neurobiology Research Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|January 13, 2025
PubMed
Summary
This summary is machine-generated.

Translocator protein (TSPO) levels decrease in stroke lesions but increase in connected and non-connected brain regions over time. Late-stage TSPO upregulation in the cerebellum correlates with chronic infarction volume after stroke.

Keywords:
MRISPECTneuroinflammationstroketranslocator protein

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Area of Science:

  • Neuroimaging
  • Molecular imaging
  • Stroke research

Background:

  • Stroke induces complex changes in brain tissue.
  • Translocator protein (TSPO) is a marker of neuroinflammation.
  • Understanding TSPO dynamics post-stroke is crucial for therapeutic development.

Purpose of the Study:

  • To longitudinally track translocator protein (TSPO) expression in various brain regions after ischemic stroke.
  • To investigate the relationship between TSPO levels and chronic brain infarction volume.

Main Methods:

  • SPECT imaging with a TSPO tracer was performed on 12 stroke patients at 10, 41, and 128 days post-infarction.
  • TSPO expression was quantified in lesional, connected, and non-connected brain regions.
  • Structural MRI was used to assess chronic infarction volume.

Main Results:

  • TSPO levels decreased in lesional regions (24%-33%) but increased significantly in connected (35%-69%) and non-connected (53%-77%) regions over 128 days.
  • A positive correlation was observed between TSPO expression in the ipsilesional cerebellum and chronic infarction volume at 128 days (r²=0.72).

Conclusions:

  • This study provides novel insights into the spatiotemporal dynamics of TSPO expression in the human brain following stroke.
  • Late-stage TSPO upregulation in specific regions is associated with the extent of chronic brain infarction.