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All or nothing: protein complexes flip essentiality between distantly related eukaryotes

Colm J Ryan1, Nevan J Krogan, Pádraig Cunningham

  • 1School of Computer Science and Informatics, University College Dublin, Ireland. colm.ryan@ucd.ie

Genome Biology and Evolution
|May 11, 2013
PubMed
Summary

Protein essentiality in yeast is often a property of molecular machines, not individual proteins. Redundancy and moonlighting explain exceptions, with essentiality patterns differing between yeast species due to lifestyle.

Keywords:
essentialitygenetic interactionsmodularityprotein complexesredundancyyeast

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