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Recurrent craniospinal subarachnoid hemorrhage in cerebral amyloid angiopathy

Mathew Alexander1, Anil Kumar B Patil, Vivek Mathew

  • 1Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India ; Department of Neurology, Christian Medical College, Vellore, Tamil Nadu, India.

Annals of Indian Academy of Neurology
|May 11, 2013
PubMed

Cerebral amyloid angiopathy (CAA) usually manifests as cerebral hemorrhage, especially as nontraumatic hemorrhages in normotensive elderly patients. Other manifestations are subarachnoid (SAH), subdural, intraventricular hemorrhage (IVH) and superficial hemosiderosis. A 52-year-old hypertensive woman presented with recurrent neurological deficits over a period of 2 years. Her serial brain magnetic resonance imaging and computed tomography scans showed recurrent SAH hemorrhage, and also intracerebral, IVH and spinal hemorrhage, with superficial siderosis. Cerebral angiograms were normal. Right frontal lobe biopsy showed features of CAA. CAA can present with unexplained recurrent SAH hemorrhage, and may be the initial and prominent finding in the course of disease in addition to superficial cortical siderosis and intracerebal and spinal hemorrhages.

Keywords:
Amyloid angiopathyconvexity bleedssubarachnoid hemorrhagesuperficial siderosis

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