Cleft palate in Williams syndrome
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Updated: May 11, 2026

Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
Scopelliti Domenico1, Cipriani Orlando, Fatone Flavia Maria Graziana
1Department of Maxillofacial Surgery, Santo. Spirito Hospital ASL RM E, Italy.
Abstract:
Williams-Beuren syndrome (WBS) is a genomic neurodevelopmental disorder, estimated to occur in approximately 1 in 10,000 persons. It is caused by a deletion of the "elastin" gene on chromosome 7q11.23 and was described officially in 1961 by Williams, Barrat-Boyes, and Lowe. Cleft palate is not considered in the medical literature as a part of the multisystem disorders of the Williams syndrome but it was yet described. We present our experience of a patient who presents cleft palate among other congenital malformations.
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