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Particulate pulmonary delivery systems containing anti-tuberculosis agents
Anuradha Gupta1, Sanketkumar M Pandya, Imran Mohammad
1CSIR Central Drug Research Institute, Lucknow 226001, India.
Critical Reviews in Therapeutic Drug Carrier Systems
|May 14, 2013
Summary
Inhaled therapies for tuberculosis (TB) show promise. This review highlights spray drying for particle engineering and handheld devices for animal studies, crucial for developing new TB treatments.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Infectious Diseases
Background:
- Renewed interest exists in pulmonary drug delivery for tuberculosis (TB).
- Particulate formulations containing anti-TB agents are being investigated.
- Challenges include particle engineering and animal model administration.
Purpose of the Study:
- To review trends in developing inhaled anti-TB therapies.
- To compare particle engineering methods for pulmonary delivery.
- To assess techniques for animal administration in TB research.
Main Methods:
- Comparison of spray drying and emulsion methods for particle preparation.
- Review of pharmaceutical characterization techniques.
- Evaluation of animal inhalation administration methods, including Animal Biosafety Level-3 (ABSL-3) considerations.
Main Results:
- Spray drying is suitable for producing inhalable anti-TB particles.
- Rigorous physicochemical characterization is essential for drug product development.
- Handheld devices are effective for pulmonary delivery in animal models.
Conclusions:
- Spray drying is a viable method for creating inhalable anti-TB drug particles.
- Comprehensive characterization is critical for successful inhaled therapy development.
- Handheld devices facilitate pulmonary delivery of anti-TB formulations in animal models, particularly within ABSL-3 settings.
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