Cellular assays for drug discovery in genetic disorders of intracellular trafficking
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Updated: May 11, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Maria Antonietta De Matteis1, Mariella Vicinanza, Rossella Venditti
1Telethon Institute of Genetics and Medicine, 80131 Naples, Italy;
Abstract:
Intracellular membrane trafficking is essential for organelle biogenesis, structure, and function; the exchange of material between organelles; and communication between the cell and its external environment. Genetic disorders affecting intracellular trafficking can lead to a variety of human diseases, but specific therapies for these diseases are notably lacking. In this article, we focus on how current knowledge about genetic disorders that affect intracellular trafficking can be used to develop strategies for cell-based assays in order to identify drugs using high-content screening approaches.
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