Developing long-acting growth hormone formulations
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Updated: May 11, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Pippa Cawley1, Ian Wilkinson, Richard J Ross
1Academic Unit of Diabetes, Endocrinology and Reproduction, University of Sheffield, Sheffield, UK.
Abstract:
Daily recombinant growth hormone (GH) restores normal growth and body composition in GH-deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children. Developing long-acting GH formulations has proved challenging, and questions remain regarding safety and efficacy. In this review, we focus on the rationale for generating long-acting GH agonists and the technologies being developed to deliver prolonged exposure to GH.
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