[Immunohistological localization of human aldolase A in human neoplastic and non-neoplastic tissues]

The expression of human aldolase A in tissues of cancer patients was examined immunohistologically using 4 monoclonal antibodies (1A2, 3C5, 1D1 and 4C2) to human aldolase A. In frozen sections, but not in paraffin sections, tumor cells of 22 out of 30 patients and non-neoplastic cells of 11 out of 21 patients examined reacted with 1A2 irrespective of cancer types. Positive reactions were seen mostly in the nucleus and some in the cytoplasm. Only tumor cells in a few neoplastic tissues gave positive cytoplasmic reactions with 1D1 or 4C2. No positive reaction was observed with 3C5. Antigens cross-reactive with aldolase A may be expressed more frequently in tumor cells than in non-neoplastic cells of cancer patients.