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[Fourth generation oral contraceptives are associated with a higher risk of venous thromboembolism compared to second
Marlene Lunddal Krogh1, Birgitte Klindt Poulsen
1Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital, Denmark. marlenelunddalkrogh@gmail.com
Abstract:
It has been widely discussed whether fourth generation oral contraceptives (OC) are associated with a higher risk of venous thromboembolism (VTE) compared to second generation. Lack of randomized controlled trials, methodological problems and inconsistent criteria for the VTE event has led to conflicting results. Three newly published studies utilising improved methodology show that fourth generation OC are associated with an increased risk of VTE compared to second generation OC. This knowledge has led to a change in recommendation of the first drug of choice, which is now second generation OC.
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