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Transthyretin and the human placenta.
K A Landers1, R H Mortimer, K Richard
1Conjoint Endocrine Laboratory, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, 4006 Brisbane, Australia. Kelly.Landers@qimr.edu.au
Placenta
|May 14, 2013
Summary
Transthyretin (TTR) is vital for transporting thyroid hormones and retinol. Recent findings highlight TTR
Area of Science:
- Biochemistry
- Endocrinology
- Reproductive Biology
Background:
- Transthyretin (TTR) is primarily known as a hepatic protein carrier for thyroid hormones and retinol.
- Emerging research indicates TTR's involvement in cerebrospinal fluid and potential roles in neurological functions.
- TTR amyloidosis encompasses several serious diseases, including senile systemic amyloidosis and familial amyloid polyneuropathies.
Purpose of the Study:
- To review the diverse functions of transthyretin (TTR).
- To explore recent findings on TTR synthesis, secretion, and uptake in the human placenta.
- To elucidate TTR's role in maternal-fetal thyroid hormone delivery.
Main Methods:
- Literature review of existing studies on transthyretin (TTR).
- Analysis of recent research on placental TTR expression and function.
- Synthesis of findings regarding TTR's role in fetal development.
Main Results:
- Transthyretin (TTR) plays a significant role in transporting thyroid hormones into the brain.
- TTR amyloidosis is linked to severe systemic and neurological diseases.
- Human placenta synthesizes, secretes, and uptakes TTR, indicating a crucial role in fetal development.
Conclusions:
- Transthyretin (TTR) has multifaceted functions beyond its traditional carrier roles.
- Placental TTR is essential for delivering maternal thyroid hormones to the developing fetus.
- Further research into TTR's placental functions may offer insights into pregnancy health and fetal development.
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