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Updated: May 11, 2026
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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
The HPV16 oncogenes cause aberrant stem cell mobilization.
Stella Michael1, Paul F Lambert, Katerina Strati
1Department of Biological Sciences, University of Cyprus, 1 University Ave., Nicosia 2109, Cyprus.
Virology
|May 14, 2013
Summary
Human Papilloma Virus (HPV) oncogenes disrupt epithelial stem cell function, causing aberrant mobilization and loss of quiescence. This creates an atypical stem cell compartment potentially driving cancer development.
Area of Science:
- Oncology
- Stem Cell Biology
- Virology
Background:
- Human Papilloma Virus (HPV) is linked to epithelial cancers.
- HPV-infected stem cells are hypothesized to be a reservoir for latent infections.
- The role of HPV oncogenes in epithelial stem cell behavior is not fully understood.
Purpose of the Study:
- To investigate the effects of HPV16 E6 and E7 oncogenes on multipotent epithelial stem cells in vivo.
- To determine if HPV oncogenes alter stem cell quiescence and mobilization.
Main Methods:
- Utilized in vivo systems to study HPV16 E6 and E7 oncogenes.
- Examined bulge label-retaining cells in hair follicles at different stages (telogen and anagen).
- Assessed stem cell markers and quiescence in the presence of oncogene expression.
Main Results:
- HPV16 oncogene expression reduced bulge label-retaining cells at telogen, indicating aberrant mobilization.
- Increased stem cell mobilization was observed upon acute anagen induction.
- Loss of stem cell quiescence occurred without a reduction in other stem cell markers.
Conclusions:
- HPV16 E6 and E7 expression leads to an atypical epithelial stem cell compartment.
- This aberrant compartment may play a significant role in HPV's life cycle and carcinogenesis.
- Further research is needed to elucidate the precise mechanisms involved.
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