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Updated: May 11, 2026

Elucidating the Metabolism of 2,4-Dibromophenol in Plants
Published on: February 10, 2023
Structural elucidation of novel degradation product of brotizolam
Yoshinori Sugimoto1, Aya Kugimiya, Yoshifumi Yoshimura
1Sanyo Chemical Laboratory Co., Ltd, Tajii, Sakai-shi, Osaka 587-0012, Japan. sugimoto@sanyokagaku.co.jp
Abstract:
When the drug product of brotizolam (1) is decomposed according to the interview form and patent, hydrolysate (2) is obtained, but its physicochemical data are still missing. To elucidate the structure based on a spectroscopic approach, the above-mentioned degradation product was isolated and applied to the structural analysis. As a result, the structure of decomposed product was found to be different from that of 2. In this report, its isolation and structure elucidation by NMR and MS spectra are described.
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