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Osteomalacia induced by adefovir in patient with hepatitis B

Mayra Nathali Rivas Zavaleta1, Sonia Guayambuco Romero1, Marcelo Calabozo Raluy1

  • 1Servicio de Reumatología, Hospital Cruces, Barakaldo, Vizcaya, España.

Reumatologia Clinica
|May 14, 2013
PubMed

Insights

Adefovir treatment for chronic hepatitis B can cause kidney issues, leading to significant phosphate loss and hypophosphatemia. This condition resulted in symptomatic osteomalacia, a bone mineralization defect.

Area of Science:

  • Nephrology
  • Endocrinology
  • Hepatology

Background:

  • Osteomalacia is characterized by defective bone matrix mineralization.
  • Chronic hepatitis B infection requires antiviral treatment.

Observation:

  • A patient with chronic hepatitis B developed renal phosphate wasting.
  • This was associated with profound and persistent hypophosphatemia during adefovir therapy.

Findings:

  • Adefovir-induced hypophosphatemia led to symptomatic osteomalacia.
  • The case highlights a rare adverse effect of adefovir treatment.

Implications:

  • Clinicians should monitor phosphate levels in patients treated with adefovir.
  • This case underscores the importance of recognizing drug-induced renal phosphate loss.
Keywords:
AdefovirHipofosfatemiaHypophosphatemiaOsteomalacia

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