Bronze baby syndrome

Daniele Ottinger1

  • 1University of Virginia Medical Center. DPS2K@HSCmail.MCC.Virginia.edu

Insights

Bronze baby syndrome (BBS) is a rare condition in newborns. This review covers its link to bilirubin and presents a case where BBS developed without high bilirubin levels.

Area of Science:

  • Neonatal Medicine
  • Biochemistry

Background:

  • Jaundice in newborns is common, with a previous review addressing its management.
  • This article focuses on bilirubin formation and bronze baby syndrome (BBS).

Observation:

  • Bronze baby syndrome (BBS) is a clinical presentation associated with severe jaundice.
  • The exact pathogenesis of BBS remains incompletely understood.

Findings:

  • BBS is characterized by a bronze discoloration of the skin and urine.
  • This review discusses current knowledge on bilirubin metabolism and BBS.
  • An unusual case of BBS developing without direct hyperbilirubinemia is presented.

Implications:

  • Understanding BBS pathogenesis is crucial for accurate diagnosis and management.
  • This case highlights the need to consider BBS even in the absence of marked hyperbilirubinemia.
  • Further research into the mechanisms of BBS is warranted.

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Parental Care00:55

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Pedigree Analysis01:35

Pedigree Analysis

Overview