Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.

Science advances·2026
Same author

The Use of Deep Learning in RNA Therapeutic Development.

ACS nano·2026
Same author

Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites.

Device·2026
Same author

The long noncoding RNA <i>lnc-FAM164A1</i>-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach.

Frontiers in immunology·2026
Same author

Tuning the immune response to mRNA vaccines.

Nature biotechnology·2026
Same author

Epidermal Patch Technologies for Integrated Healthcare and Infection Management.

Advanced healthcare materials·2026
Same journal

Shear-Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks.

Advanced functional materials·2026
Same journal

Buckling-Resistant and Trace-Stacked (BRATS) Design Enables Aid-Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response.

Advanced functional materials·2026
Same journal

Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organs.

Advanced functional materials·2026
Same journal

Benchtop Fabrication and Integration of Laser-Induced Graphene Strain Gauges and Stimulation Electrodes in Muscle on a Chip Devices.

Advanced functional materials·2026
Same journal

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites.

Advanced functional materials·2026
Same journal

Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.

Advanced functional materials·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

A Stiff Injectable Biodegradable Elastomer.

Boaz Mizrahi1, Sahadev A Shankarappa, Julia M Hickey

  • 1Prof. Daniel S. Kohane, Dr. B. M., Dr. S. A. S., J. H., J. D., Dr. B. P. T., Dr. J. L. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

Advanced Functional Materials
|May 14, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a novel water-free injectable material made from PEG-dopamine. This injectable material offers tunable mechanical properties and sustained drug release, showing promise for biomedical applications.

Keywords:
Biomedical ApplicationsBiomimeticsDrug DeliveryHydrogelsPolymeric Materials

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Related Experiment Videos

Last Updated: May 11, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Injectable materials often face limitations in mechanical strength and drug elution due to high water content.
  • Developing water-free injectable systems is crucial for overcoming these challenges in biomedical applications.

Purpose of the Study:

  • To develop and characterize a novel water-free, injectable hydrogel system based on polyethylene glycol (PEG) modified with dopamine.
  • To evaluate the material's mechanical properties, drug-elution capabilities, and in vivo biocompatibility for potential use in drug delivery.

Main Methods:

  • A liquid, four-armed PEG modified with dopamine end groups was synthesized.
  • The liquid precursor was cross-linked into an elastic solid using ferric ions (Fe3+).
  • Mechanical properties (elastic modulus) and degradation rates were tuned by varying Fe3+ concentration. Lidocaine was incorporated, and its release kinetics were studied. In vivo subcutaneous implantation in rats was performed to assess retention and inflammation.

Main Results:

  • The PEG-dopamine material transitioned from a liquid to an elastic solid upon addition of Fe3+.
  • Increasing Fe3+ concentration enhanced elastic modulus and degradation time.
  • Sustained release of both free base and water-soluble lidocaine was achieved from the cross-linked matrix.
  • The material demonstrated retention in vivo for up to 3 weeks with minimal observed inflammation.

Conclusions:

  • The developed water-free PEG-dopamine system offers tailorable mechanical properties and controlled drug release.
  • Its biocompatibility and ability to incorporate diverse drugs make it a promising candidate for advanced drug delivery and other biomedical applications.