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Updated: May 11, 2026
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation
Shigeyuki Murono1, Akira Tsuji, Kazuhira Endo
1Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Japan.
Objectives/Hypothesis:
The association of special AT-rich binding protein 1 (SATB1) with a poor prognosis in various cancers has been reported. However, this association is controversial. SATB1 expression in aggressive types of thyroid cancer has not been reported to date.
Study Design:
Retrospective.
Methods:
SATB1 expression was immunohistochemically investigated in 35 papillary thyroid cancers, one follicular thyroid cancer, six poorly differentiated thyroid cancers, and two anaplastic thyroid cancers.
Results:
SATB1 expression was observed in none of two anaplastic thyroid cancers, one of six poorly differentiated thyroid cancers, and nine of 36 well-differentiated thyroid cancers. SATB1 expression was not significantly associated with any high-risk group-related clinicopathologic factors in well-differentiated thyroid cancer. Survival was not associated with SATB1 expression.
Conclusions:
SATB1 expression is independent of thyroid cancer differentiation, as well as high-risk-related factors. SATB1 may not play a role in the aggressiveness of thyroid cancer.
