Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Postsynaptic Potential (PSP)

Postsynaptic Potential (PSP)

Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...

Psychotherapy

Psychotherapy

Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...

Defining Psychology

Defining Psychology

Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...

Psychology as a Science

Psychology as a Science

Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...

Interpersonal Psychotherapy

Interpersonal Psychotherapy

Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.

Psychodynamic Therapy

Psychodynamic Therapy

Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Potential of Digital Twins for Pediatric Rare Diseases.

CPT: pharmacometrics & systems pharmacology·2026

Same author

From FAIR to CURE: guidelines for computational models of biological systems.

NPJ systems biology and applications·2026

Same author

The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell.

Genomics, proteomics & bioinformatics·2026

Same author

Application of Large Language Models for Annotating Genes into Reactome Pathways.

bioRxiv : the preprint server for biology·2026

Same author

CIA: unveiling cellular identities with cluster-independent annotation in single-cell RNA sequencing data for comprehensive cell type characterization and exploration.

BMC bioinformatics·2025

Same author

Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration.

Nucleic acids research·2025

Search research articles

Related Experiment Video

Updated: May 11, 2026

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

A new reference implementation of the PSICQUIC web service.

Noemi del-Toro¹, Marine Dumousseau, Sandra Orchard

¹EMBL-European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK. ntoro@ebi.ac.uk

Nucleic Acids Research

|May 15, 2013

Summary

The Proteomics Standard Initiative Common QUery InterfaCe (PSICQUIC) specification has been updated to version 1.3, enhancing access to over 150 million molecular interaction records. This update improves data accessibility and user experience for researchers worldwide.

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Related Experiment Videos

Last Updated: May 11, 2026

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

Proteomics
Bioinformatics
Computational Biology

Background:

The Human Proteome Organization Proteomics Standards Initiative (HUPO-PSI) developed the Proteomics Standard Initiative Common QUery InterfaCe (PSICQUIC) to standardize computational access to molecular interaction data.
PSICQUIC utilizes a standard Web Service and query language, currently aggregating over 150 million binary interaction evidences from 28 global servers.
Existing PSICQUIC allows concurrent searching of multiple molecular interaction information resources via a single query.

Purpose of the Study:

To present an extension of the PSICQUIC specification (version 1.3) to align with enhanced standards in molecular interactions.
To introduce a new reference implementation of the PSICQUIC server for data providers, offering augmented web service capabilities.
To improve the overall user experience for accessing and querying molecular interaction data.

Main Methods:

Extension of the existing PSICQUIC specification to version 1.3.
Development of a new reference implementation for the PSICQUIC server.
Demonstration of capabilities through the PSICQUIC View web application for simultaneous querying, browsing, and downloading of results.

Main Results:

The PSICQUIC specification has been updated to version 1.3, ensuring compliance with enhanced molecular interaction standards.
A new reference PSICQUIC server implementation is available, providing improved web service capabilities and user experience.
The PSICQUIC network has grown to 28 data providers, offering access to over 151 million binary interactions.

Conclusions:

The updated PSICQUIC specification (v1.3) enhances the accessibility and standardization of molecular interaction data.
The new server implementation and PSICQUIC View application improve data provider capabilities and user interaction.
PSICQUIC continues to be a vital resource for computational access to large-scale molecular interaction data.