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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

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Related Experiment Video

Updated: May 11, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Heart failure: what does ejection fraction have to do with it?

Hiroyuki Iwano1, William C Little

  • 1Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1045, USA.

Journal of Cardiology
|May 16, 2013
PubMed
Summary

Heart failure (HF) affects patients with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Therapies effective for HFrEF do not work for HFpEF, highlighting the need for new HFpEF treatments.

Keywords:
Ejection fractionHeart failureHeart failure with preserved ejection fraction

Related Experiment Videos

Last Updated: May 11, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biomedical Science

Background:

  • Heart failure (HF) presents across the spectrum of left ventricular (LV) ejection fractions (EF), including HF with preserved EF (HFpEF).
  • HFpEF accounts for nearly half of all HF cases, characterized by normal LV end-diastolic volume relative to stroke volume.
  • Diastolic dysfunction is a universal finding in HF, irrespective of EF.

Purpose of the Study:

  • To differentiate HFpEF from HF with reduced EF (HFrEF).
  • To review current therapeutic strategies and their efficacy in HFpEF.
  • To identify potential new treatment targets for HFpEF.

Main Methods:

  • Review of existing literature on HF pathophysiology and treatment.
  • Analysis of the mechanisms underlying HFpEF and HFrEF.
  • Exploration of novel therapeutic pathways, including c-GMP modulation and comorbidity management.

Main Results:

  • Standard HFrEF therapies (ACE-inhibitors, ARBs, beta-blockers, CRT) are ineffective in HFpEF.
  • HFpEF is characterized by preserved EF with normal LV volumes, contrasting with the dilated LV in HFrEF.
  • Comorbidities play a significant role in HFpEF and represent potential therapeutic targets.

Conclusions:

  • HFpEF requires distinct therapeutic approaches compared to HFrEF due to differences in underlying pathophysiology.
  • Targeting c-GMP pathways and managing comorbidities are promising strategies for HFpEF treatment.
  • Further research is needed to develop effective therapies for the growing HFpEF population.