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Related Concept Videos

Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...

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Related Experiment Video

Updated: May 11, 2026

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
12:48

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

Published on: September 12, 2015

GLP-2 and mesenteric blood flow.

Lasse Bremholm Hansen1

  • 1Department of Gastroenterology, Køge Hospital, Lykkebækvej 1, 4600 Køge, Denmark. lasssbremholm@dadlnet.dk

Danish Medical Journal
|May 16, 2013
PubMed
Summary
This summary is machine-generated.

Glucagon-like peptide-2 (GLP-2) significantly increases mesenteric blood flow in healthy individuals and short bowel syndrome (SBS) patients, similar to a standard meal. This peptide hormone also elevates cardiac output and pulse rate without affecting blood pressure.

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Last Updated: May 11, 2026

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Area of Science:

  • Physiology
  • Gastroenterology
  • Endocrinology

Background:

  • Glucagon-like peptide-2 (GLP-2) is a peptide hormone produced by enteroendocrine L-cells, primarily in the ileum and colon.
  • GLP-2 exerts its biological effects via a G-protein-coupled 7-transmembrane receptor, found in various organs including the brainstem, lungs, stomach, small intestine, and colon.
  • Previous animal studies indicate GLP-2 infusion enhances intestinal blood flow, specifically within the small intestine.

Purpose of the Study:

  • To investigate the physiological effects of GLP-2 on mesenteric blood flow, other vascular sites, and cardiac parameters in healthy volunteers and patients with short bowel syndrome (SBS).
  • To evaluate these parameters following both meal stimulation and GLP-2 administration.

Main Methods:

  • Three studies were conducted involving healthy volunteers and SBS patients.
  • Mesenteric blood flow, including changes in the superior mesenteric artery (SMA), was assessed.
  • Cardiovascular parameters such as blood pressure, cardiac output (CO), and stroke volume (SV) were measured, with impedance cardiography used in some studies.

Main Results:

  • GLP-2 administration led to rapid and significant increases in mesenteric blood flow in the SMA, comparable to responses seen after a standard meal.
  • No significant changes in blood pressure were observed, but increases in CO and SV were noted.
  • The vascular response in the SMA was less pronounced in SBS patients compared to healthy subjects and correlated with the length of remaining intestine.

Conclusions:

  • GLP-2 is a potent regulator of upper splanchnic blood flow, with effects secondary to metabolic responses likely mediated by paracrine actions.
  • GLP-2 increases mesenteric blood flow in a dose-dependent manner, equivalent to a standard meal, but does not affect blood flow at other arterial sites.
  • GLP-2 acutely increases pulse rate and cardiac output, likely as a compensatory mechanism, without altering blood pressure.