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Updated: May 11, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward
John R Ingram1, Vincent Piguet
1Department of Dermatology and Wound Healing, Institute of Infection and Immunity, Cardiff University, Cardiff, UK. ingramjr@cardiff.ac.uk
Abstract:
Awareness is increasing that there is phenotypic heterogeneity within the hidradenitis suppurativa (HS) disease spectrum. However, the few randomized HS trials that are available have not distinguished between the subtypes of the disease. In this issue, Canoui-Poitrine et al. used latent class (LC) analysis of the largest HS cohort described to date to generate three phenotypic subtypes. LC 1 correlates with "typical" European HS, mainly involving the axilla, groin, and, in women, the inframammary region. "Atypical" HS, which may be linked to γ-secretase gene mutations, was subdivided further into LC2 and LC3 subtypes.
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