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Updated: May 11, 2026

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
05:52

Reconstitution of Msp1 Extraction Activity with Fully Purified Components

Published on: August 10, 2021

A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties

Lawrence Kazak1, Aurelio Reyes, Jiuya He

  • 1MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom.

Plos One
|May 16, 2013
PubMed
Summary

A new mitochondrial Flap endonuclease 1 (FEN1) isoform, FENMIT, is generated by alternative translation. This isoform targets mitochondria and interacts with RNA/DNA hybrids, impacting mitochondrial DNA replication.

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