[Clinical characteristics and antibiotic resistance in children with invasive Acinetobacter baumannii infection]
1Department of Respiratory Medicine, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.
Insights
Invasive Acinetobacter baumannii infection (IABI) predominantly affects infants and often presents with severe underlying conditions. High rates of multi-drug and pan-drug resistance in IAB strains pose significant treatment challenges.
Area of Science:
- Pediatric Infectious Diseases
- Antimicrobial Resistance
- Clinical Microbiology
Background:
- Invasive Acinetobacter baumannii infection (IABI) is a significant concern in pediatric populations.
- Understanding the clinical spectrum and resistance patterns is crucial for effective management.
Purpose of the Study:
- To analyze the clinical characteristics of pediatric IABI.
- To investigate the antibiotic resistance patterns of Acinetobacter baumannii strains in children.
Main Methods:
- Retrospective analysis of clinical and drug sensitivity data.
- Involved 52 pediatric cases of IABI from January 2004 to December 2011.
Main Results:
- IABI predominantly affected children under one year old (67%) and was frequently hospital-acquired (90%).
- Common diagnoses included septicemia (37%), urinary tract infection (31%), and skin/soft tissue infection (23%).
- High rates of multi-drug (21%) and pan-drug resistance (17%) were observed, though sensitivity to amikacin remained high.
Conclusions:
- IABI in children is common in infants, often associated with underlying diseases, and predominantly hospital-acquired.
- Septicemia, UTIs, and skin infections are key clinical presentations.
- Severe multi-drug and pan-drug resistance in Acinetobacter baumannii strains necessitates careful antibiotic selection.
Objective:
To analyze the clinical characteristics and antibiotic resistance in children with invasive Acinetobacter baumannii infection (IABI).
Methods:
A retrospective analysis was performed on the clinical and drug sensitivity data of 52 children with IABI between January 2004 and December 2011.
Results:
Of the 52 children with IABI, 35 (67%) were less than one year old and 35 (67%) had IABI in the summer and autumn, 19 (37%) of these children were clinically diagnosed with septicemia, 16 (31%) with urinary tract infection, and 12 (23%) with skin and soft tissue infection, and 38 (73%) of them suffered from underlying diseases. The incidence rates of hospital-acquired and community-acquired IABIs were 90% and 10% respectively; 44 cases (85%) were cured or showed improvement in symptoms, and 8 cases (15%) died. All the IAB strains isolated from these children were sensitive to amikacin, 82% of them were sensitive to imipenem, more than 70% were sensitive to fluoroquinolone and to cefoperazone/sulbactam, 13% were sensitive to cefoperazone, 8% were sensitive to aztreonam, 21% developed multidrug resistance, and 17% developed pan-drug resistance.
Conclusions:
IABI occurs more frequently in children under one year of age, and most children with IABI have underlying diseases. IABI mainly results in septicemia, urinary tract infection and skin and soft tissue infection and is mostly hospital-acquired. Multi-drug resistance and pan-drug resistance are severe in IAB strains.
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