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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

[Promises and challenges in developing MiRNA as a molecular diagnostic tool for lung cancer]

William C S Cho1

  • 1Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong. chocs@ha.org.hk

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|May 17, 2013
PubMed
Abstract

No abstract available in PubMed .

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MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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