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Psychosurgery01:30

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Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate measurements...
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Updated: May 11, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Psychiatry's Catch 22, Need For Precision, And Placing Schools In Perspective.

Ajai R Singh1

  • 1MD, Editor, MSM, India.

Mens Sana Monographs
|May 17, 2013
PubMed
Summary
This summary is machine-generated.

Psychiatry faces a diagnostic dilemma: precise tests require precise criteria, and vice versa. The path forward lies in relentless pursuit of biological correlates and brain mechanisms for psychiatric disorders.

Keywords:
BiologyBrainControlDSM-5Diagnostic CategoriesDisorderICD-11Investigative testsMedicalisationMindNeurobiological correlatesPsychosocial factorsSchools of psychiatryWell-being

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics
  • Molecular Biology

Background:

  • Current psychiatric diagnostics lack precision, creating a 'catch-22' situation where definitive tests require clear criteria, and vice versa.
  • Existing investigative tools (psychological, serum, CSF, neuroimaging) are largely corroborative, not definitive.
  • Diagnostic proliferation and ambiguity are exacerbated by medicalization and the need to accommodate diverse interests in diagnostic manuals like DSM-5 and ICD-11.

Purpose of the Study:

  • To advocate for a relentless pursuit of precision in psychiatric diagnostics and investigative tests.
  • To emphasize the critical need for biological correlates and a deeper understanding of brain mechanisms in psychiatric disorders.
  • To guide future research directions towards deciphering the phenotype-genotype-endophenotype axis and the neurobiological underpinnings of psychiatric conditions.

Main Methods:

  • Focus on identifying precise biological markers and understanding the phenotype-genotype-endophenotype axis.
  • Investigating critical brain processes, neuronal cellular and molecular mechanisms involved in psychiatric malfunction and restoration.
  • Integrating insights from neuroimaging, molecular neurobiology, neurogenomics, and psychopharmacology with psychosocial, cognitive, and behavioral approaches.

Main Results:

  • The abstract posits that breakthroughs in psychiatric etiology and therapeutics will primarily stem from biological and psychopharmacological research.
  • It highlights the necessity of understanding how diverse forces (genetic, environmental, social) impact brain function leading to psychiatric disorders.
  • The research emphasizes that progress in brain research must parallel progress in understanding the 'mind' and its manifestations.

Conclusions:

  • The future of psychiatry hinges on deciphering the brain's intricate mechanisms underlying psychiatric disorders.
  • A rigorous, science-based approach prioritizing biological precision is essential for advancing psychiatric diagnosis and treatment.
  • Understanding the interplay between brain function, genetic predispositions, environmental factors, and psychosocial influences is key to restoring mental health.