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Related Experiment Video

Updated: May 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

[Cardiac resynchronization therapy in women].

Maurizio Lunati¹, Maurizio Landolina, Manlio Cipriani

¹Dipartimento Cardiotoracovascolare A. De Gasperis, A.O. Ospedale Niguarda Ca' Granda, Milano. maurizio.lunati@ospedaleniguarda.it

Giornale Italiano Di Cardiologia (2006)

|May 18, 2013

Summary

Cardiac resynchronization therapy (CRT) offers survival benefits for heart failure patients. Women appear to experience greater survival advantages from CRT compared to men, suggesting increased access for appropriate female candidates.

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Area of Science:

Cardiology
Medical Devices
Clinical Trials

Context:

Cardiac resynchronization therapy (CRT) is established for heart failure (NYHA class III-IV, LVEF ≤35%, QRS >120 ms).
Limited data exist on sex-based differences in CRT response.
Women are underrepresented in CRT clinical trials (<30%).

Purpose:

To investigate potential sex differences in response to cardiac resynchronization therapy.
To evaluate if women experience distinct benefits from CRT compared to men.

Summary:

Recent studies and current data suggest women may have a more positive response and greater survival benefit from CRT.
Potential reasons for this difference are under investigation, including intrinsic female factors, clinical characteristics, and cardiomyopathy prevalence.

Impact:

Current evidence supports increasing access to CRT for women with appropriate indications.
Further research, including larger trials, is needed to fully elucidate the gender effect in CRT response.