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[Selective serotonin reuptake inhibitor and gastrointestinal hemorrhage]
Takatsugu Yamamoto1, Koichiro Abe, Yasushi Kuyama
1Department of Internal Medicine, Teikyo University.
Abstract:
Selective serotonin reuptake inhibitors (SSRI) are widely used antidepressants characterized by less-frequent adverse effects compared with classical anti-depressive agents. On the other hand, SSRI can cause hemorrhagic events more due to impaired platelet aggregation induced by a depletion of serotonin in the peripheral platelet. Epidemiological studies have indicated that patients taking SSRI are predisposed to gastrointestinal hemorrhage, especially in case that nonsteroidal anti-inflammatory drugs are prescribed concomitantly. Here we describe a risk of the gastrointestinal hemorrhage in patients taking SSRI.
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