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Updated: May 11, 2026
11:42
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
[Epithelial-mesenchymal transition in prostate cancer]
Li Liu1, Li-Ling Wang, Xiao-Guang Yu
1Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China. 1227991085@qq.com
Zhonghua Nan Ke Xue = National Journal of Andrology
|May 18, 2013
Summary
Prostate cancer (PCa) metastasis, a leading cause of death, is driven by epithelial-mesenchymal transition (EMT). Understanding EMT factors is key to developing new PCa treatments.
Area of Science:
- Oncology
- Cell Biology
- Cancer Research
Context:
- Prostate cancer (PCa) is a prevalent malignancy in elderly men, with rising incidence in China.
- Tumor metastasis significantly contributes to PCa patient mortality.
- Tumor cells interact with their microenvironment, initiating epithelial-mesenchymal transition (EMT) and metastasis.
Purpose:
- To review recent literature (last 3 years) on factors influencing EMT in prostate cancer.
- To explore the role of EMT in prostate cancer development and progression.
- To identify potential therapeutic targets for PCa treatment based on EMT.
Summary:
- This review examines the critical role of epithelial-mesenchymal transition (EMT) in prostate cancer (PCa) progression and metastasis.
- It synthesizes findings on various factors that modulate EMT in the context of PCa.
- The overview highlights the significance of EMT for understanding PCa pathogenesis.
Impact:
- Provides insights into the mechanisms of prostate cancer metastasis.
- Identifies potential therapeutic strategies targeting EMT pathways for improved PCa treatment.
- Contributes to the ongoing research efforts aimed at combating prostate cancer mortality.
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