Andrographidine G, a new flavone glucoside from Andrographis paniculata.

Area of Science:

• Natural Product Chemistry
• Phytochemistry
• Medicinal Plant Research

Background:

• Andrographis paniculata is a plant known for its medicinal properties.
• Previous research has identified various bioactive compounds from this species.
• Further investigation is needed to fully characterize its chemical constituents.

Purpose of the Study:

• To isolate and identify novel and known compounds from Andrographis paniculata.
• To elucidate the chemical structure of a newly discovered flavone glucoside.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation of the new compound (andrographidine G) via High-Resolution Electrospray Ionization Time-of-Flight Mass Spectrometry (HR-ESI-TOF-MS).
• Confirmation of structure using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy and chemical methods.
• Identification of known compounds through comparative analysis.

Main Results:

• A new flavone glucoside, named andrographidine G, was successfully isolated.
• The structure of andrographidine G was rigorously determined using spectroscopic and spectrometric analyses.
• Thirteen known compounds, including flavonoids, diterpenoids, and iridoids, were also identified.

Conclusions:

• The chemical profile of Andrographis paniculata has been expanded with the discovery of andrographidine G.
• The study confirms the presence of a diverse range of secondary metabolites in the plant.
• This research contributes to the understanding of the phytochemical diversity of Andrographis paniculata.